Rotundine
Product name: Rotundine
CAS#10097-84-4
Molecular Formula: C21H25NO4
Molecular Weight: 355.43g/mol
Melting point: 141 ~144 ℃
English alias:Tetrahydropalmatine;
Rotundine; 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-6h-dibenzo[a,g] quinolizine
Rotundine, This product is white or slightly yellow crystalline; odorless, tasteless; in case of light heat labile yellow. The product is dissolved in chloroform, slightly soluble in ethanol or ether, insoluble in water; soluble in dilute sulfuric acid. For gastric ulcer and duodenal ulcer pain, menstrual pain, childbirth uterine contraction pain, nervous insomnia, spastic cough.
The product is 2,3,9,10- tetramethoxy -5,8,13,13a- hydrogen four - 6H - two benzo [a, g] quinolizine. According to the dry matter calculation, C21H25NO4containing not less than 98%
specific rotation: Take the goods, accurately weighed, add ethanol dissolution and quantitative diluted solution containing 8mg per 1ml, according to the determination at 25 degrees C (Appendix VI E), specific rotation of -290 to -300 deg.
Pharmacological action: Rotundine, Has analgesic, sedative, hypnotic and stability. The analgesic effect was weaker than pethidine, stronger than the general antipyretic analgesic. In therapeutic doses of the inhibitory effects of breathing, also does not cause gastrointestinal smooth muscle spasm. Good effect on the dull pain of chronic persistent pain and visceral, on acute sharp pain (such as post operation pain, traumatic pain), a poor effect of pain in advanced cancer. The analgesic effects at the same time, can cause sedation and hypnosis. Mechanism of action of the product remains to be elucidated, probably through inhibition of the brainstem and the ascending reticular activating system, block dopamine receptors in the brain function. The amount of no addiction treatment.