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Norcantharidin
Norcantharidin
Product name: Norcantharidin
CAS#5442-12-6 Purity:98%
Molecular Formula:C18H18NO4
Molecular Weight:168.14/mol
Properties: Colorless crystalline powder, no odor, slightly irritating. Slightly soluble in water and ethanol, soluble in hot water, acetone
English alias:7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic ;Anhydride;
4,10-Dioxatricyclo[5.2.1.0(2,6)]decane-3,5-dione; hexahydro-4,7-epoxy-2-benzofuran-1,3-dione; (3aR,4S,7R,7aS)-hexahydro-4,7-epoxy-2-benzofuran-1,3-dione。
usage: Oral administration: 5 times 1 ~ 20mg (severe can be added to 30mg), 3, 1 times, fasting service. Intravenous or intravenous drip: 1, 10 ~ 20mg, dissolved in the appropriate glucose injection in slow bolus injection, or addition of glucose injection 250 ~ 500ml slowly drip.
Note: Adverse reactions are rare, but the oral dose is too large may appear nausea, vomiting and other symptoms, should be reduced or discontinued.
Preparation:Tablet: each tablet 5mg. Injection: each 10mg (2ml).
Quality control methods.
By HPLC, chromatographic column C18 column (5 m, 4.6 mm x 250 mm) and the detection wavelength for 211 nm. The mobile phase was: water: ethanol (85: 15), the phosphate regulating pH to 3-1. Results cantharidin in 80 to 1 000mg*L-1 within the scope of a linear method for the fast.
Synthesis of possible routes: the reaction of with D-A reaction by heating reflux with maleic anhydride and maleic anhydride
Haoxiang Bio Production specifications: 20mg, 50mg, 100mg, 1g, 10g, 100g, 1kg, 50kg
Packing: Aluminum foil, plastic