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Camptothecine
Camptothecine
Product name: Camptothecine
CAS#7689-03-4 Purity:15%--98%
Molecular Formula:C20H16N2O4
Molecular Weight:348.34g/mol
English alias:
4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (+)-Camptothecin; Camptothecin, Camptotheca acuminata; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin,95%; Camptothecin;
Chemical name:
1H-Pyrano[34:6,7]indolizino[1,2-6]puinoline-3,14(4H,12H-)-dione,4-ethy1-4-hydroxy-(s)-
Plant origin: fruit and leaf of acuminata Decne Camptotheca, a plant of the genus.
Camptothecine is a kind of anticancer drug, extracted from the distribution of the Central South and southwest of China. In 1976, Chinese chemists Gao Yisheng and other synthetic. Camptothecin has better curative effect on the gastrointestinal tract and head and neck cancer and other side effects, but there is blood in the urine of a few patients. The anticancer activity of 10- is more than that of the base, and has obvious curative effect on liver cancer and head and neck cancer, and the side effect is less.
Physical and chemical properties: Light yellow needle crystal (methanol - acetonitrile), decomposition point: 264℃ to 267℃, [a +31.3]25D. (chloroform methanol). Intense blue fluorescence, and acid can not generate stable salt.
Pharmacological action: Anti tumor, immune suppression, anti-virus, anti early pregnancy, to change the skin and skin of the process of change. Clinical application: for malignant tumor, psoriasis, cure warts, caused by acute and chronic leukemia and schistosomiasis hepatosplenomegaly.
Adverse reactions: the amount of above 100 mg can cause loss of appetite, nausea, vomiting, gastroenteritis; can inhibit the bone marrow, cause hemorrhagic cystitis, occurrence frequent micturition, dysuria and hematuria; cause oral mucosal infection and hair loss.
Haoxiang Bio Production specifications: 20mg, 50mg, 100mg, 1g, 10g, 100g, 1kg, 50kg
Packing: Aluminum foil, plastic