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Andrographolide
Andrographolide
Product name: Andrographolide
CAS#5508-58-7
Molecular Formula: C20H30O6
Molecular Weight: 350.44 g/mol
The main effective components of natural plant Andrographis, has the functions of eliminating heat detoxification, anti-inflammatory and analgesic effect, and has special effect on bacterial and viral infection of the upper respiratory tract and dysentery, known as natural antibiotics. This product is two terpene lactone compounds are insoluble in water, can only oral administration.
Chemical name:
293H)-Furanone,3-[2-[decahydro-6-hydroxy-5-(hydroxy-methyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-
operative norm: WS-10001-(HD-0971)-2002
Plant source: Acanthaceae plant Andrographis Andrographis Paniculata (Burm.f) Ness full of grass or leaves.
Physical property: The white square prism or flaky crystal (ethanol or methanol), odorless, bitter taste. Dissolved in boiling alcohol, slightly soluble in methanol or ethanol, soluble in chloroform, insoluble in water or ether. The melting point of 230 to 231 DEG C (alpha), 17D -126.6 (Bing Cusuan), plus or minus 2 degrees [alpha]D - 112.7 (C, 0.53, MeOH), and alkaline 2% 3,5 two Nitrobenzoic Acid reagent, a purplish red color, hydroxamic acid iron positive. Density (21 DEG C) 1.2317g/cm3. UV lambda EtOHmax nm (E), 223 (12300); IRvKBrmax cm-1: 34483390 to? 279 (OH), 18281647906 (C=CH2), 1727 (alpha, beta unsaturated gamma lactone), 1672 (CO C=C); 13CNMR.
Haoxiang Bio production process: Andrographis Herb leaf dipped in 95% ethanol, the ethanol soaking liquid taking decolorized with activated carbon, decolorization liquid distillation recovery after ethanol concentration liquid static to obtain coarse crystal, coarse grain adding 15 times amount of 95% alcohol heating to dissolve, activated carbon decolorization, filtered while hot, static recrystallization, pale yellow crystal heavy node, and then the distilled water, chloroform, methanol washing refined andrographolide product. The total yield of crude drug, 1-1.5%.
Pharmacological action:Andrographolide as main effective components of natural plant Andrographis, has the functions of eliminating heat detoxification, anti-inflammatory and analgesic effect, and has special effect on bacterial and viral infection of the upper respiratory tract and dysentery, known as natural antibiotics. This product is two terpene lactone compounds are insoluble in water, can only oral administration.